Ms Aarti V Belgamwar,Dr Shagufta A Khan,Dr Pramod G Yeole
申请号：
IN201621041883
公开号：
IN201621041883A
申请日:
2016.12.07
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
The present invention relates to development Intranasal nanoparticles of efavirenz using water soluble CS-g-HPCD as a nanocarrier. Low sized, stable nanoparticles with high drug loading is prepared using CS-g-HPCD. Sustained release from the nanoparticles and enhanced permeation through the nasal mucosa of EFV could be achieved without adverse effect on it. Significantly greater access of EFV to the CNS and high drug targeting index to the brain from intranasal EFV loaded CS-g-HPCD nanoparticles makes it a promising gateway for targeting the CNS in Neuro-AIDS.
