MOLECULE DE LIAISON D'ANTIGENE DESTINEE A FAVORISER LA DISPARITION D'ANTIGENE VIA LE RECEPTEUR FC.GAMMA.RIIB

• 收藏
• 分享

专利权人:

CHUGAI SEIYAKU KABUSHIKI KAISHA

发明人:

IGAWA, TOMOYUKI,MAEDA, ATSUHIKO,IWAYANAGI, YUKI,HARAYA, KENTA,KATADA, HITOSHI,KADONO, SHOJIRO,MIMOTO, FUTA

申请号：

CA2865158

公开号：

CA2865158A1

申请日:

2013.02.22

申请国别(地区):

CA

年份:

2013

代理人:

摘要：

The invention provides: an antigen-binding molecule containing (i) an antigen-binding domain for changing the binding activity in relation to an antigen depending on the conditions of ion concentration, (ii) an Fc?-binding domain having Fc?RIIb selective binding activity, and (iii) an FcRn-binding domain having binding activity in relation to FcRn under the conditions of a pH acidic region； and a method for lowering the concentration of an antigen in the plasma in comparison with before administration of the molecule, the method comprising administering the molecule.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/