抗CHIKV抗體及其用途农业专利-农业学术服务平台

发明人:: CARTER, KARA,卡特　卡拉,卡特　卡拉,LEMOINE, CENDRINE,勒莫因　桑德里纳,勒莫因　桑德里納,MANDRON, MARIE,曼德隆　玛莉,曼德隆　瑪莉,PARK, SUNGHAE,朴晟惠,朴晟惠,QIU, HUAWEI,邱　华伟,邱　華偉,ROTHBLATT, JONATHAN,罗素布雷特　强纳森,羅素布雷特　強納森

摘要：: The present invention concerns antibodies and antigen-binding fragments of antibodies which specifically bind to and neutralize Chikungunya virus (CHIKV) and which are engineered to develop therapeutics in order to treat CHIKV disease or prevent CHIKV infection. The invention also relates to pharmaceutical compositions comprising antibodies of the invention and the use of the antibodies for the prevention and treatment of CHIKV disease.本發明涉及抗體和抗體的抗原結合片段，所述抗體和抗體的抗原結合片段特異性結合並中和基孔肯雅病毒(Chikungunya virus,CHIKV)並經工程化以開發療法進而治療CHIKV疾病或預防CHIKV感染。本發明還涉及包含本發明的抗體的藥物組合物和所述抗體用於預防和治療CHIKV疾病的用途。