Korea Institute of Radiological & Medical Sciences
发明人:
申请号：
GB202001444
公开号：
GB202001444D0
申请日:
2018.02.28
申请国别(地区):
GB
年份:
2020
代理人:
摘要：
The present invention relates to a composition for preventing or treating cancer containing a triazolopyridine-based derivative or a pharmaceutically acceptable salt thereof as an active ingredient, wherein the triazolopyridine-based derivative inhibits tankyrase enzyme activity to suppress the expression of β-catenin, which is a tumor factor, thereby increasing cancer cell death by apoptosis. Due to exhibiting excellent survival rate reduction when used in combination with anti-cancer drugs or irradiation, the triazolopyridine-based derivative can be usefully used as a pharmaceutical composition for preventing and treating cancer, a composition for increasing the effect of radiation therapy, or a health functional food for preventing or improving cancer.
