1. This product provides various compounds and methods to treat a disease related to the inhibition of quinolase activity, for example, a disease related to the inhibition of thyroid hormone quinolase activity, for example, enzyme hormone hormone hormone hormone hormone hormone hormone hormone hormone hormone hormone hormone hormone hormone hormone hormone hormone hormone hormone hormone hormone hormone hormone hormone hormone hormone hormone hormone hormone hormone hormone hormone hormone hormone hormone hormone A disease related to the inhibitory activity of the growth factor receptor thyroid hormone 500 enzyme, for example, a disease related to the inhibition of the signal of the thyroid hormone quinase receptor, or a disease related to the inhibition of the signal of the VEGF receptor. 1. Claim 1: compound according to formula (1),including N-oxides, hydrates, solvates, tautomers, pharmaceutically acceptable salts, prodrugs and their complexes and racemic and endemic mixtures, their diastereomers and enantiomers, wherein, D is selected from the group consisting of a system of aromatic, heteroaromatic, cycloalkyl rings or heterocyclic, C₁₋₆-heterocyclyl-C (O) alkyl -,1. C833218331c8326 heterosexual asphalt c83321c83126n-n (r8310a) - C (o) -,(r8310) (r8310) N-C (o) - o-straight bike-c (o) - straight bike-c (o)-Direct-c (o) -,1. C833218331-832626-o (o) - straight ring-c (o) -,1. C-83218331-c (o) - n (r83100a) - heterosexual-c (o) -,(Alquil C) (Box) N-heterociclil-C (O) -HO-heterocyclyl-C (O) -,Ho-c (o) - straight ring-c (o)1. C83218331-c (o) - o-straight ring-c (o) -,(R⁶) (R⁶) N-C₁₋₆-N (R⁶) -C (O) -heterocyclyl-C (O) -,e. C83218331-832626-heterosexual-c (o) - heterosexual-c (o) - and (r8310a) (r8310a) n-heterosexual-c (o),a. Each aromatic, heteroaromatic, cyclopropyl or heterocyclic aromatic group can be replaced by one or more independently selected r03831222；M is an optional aperiodic merge remainder； Z is from - O--S (O) - y -NR -wherein R⁵ is selected from the
