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Antiviral agent for hepatitis B
- 专利权人:
- INC.;NOVIRA THERAPEUTICS
- 发明人:
- GEORGE D. HARTMAN,OSVALDO A. FLORES
- 申请号：
- ARP120104951
- 公开号：
- AR090044A1
- 申请日:
- 2012.12.21
- 申请国别(地区):
- AR
- 年份:
- 2014
- 代理人:
- 摘要：
- Claim 1: A compound characterized in that it is of formula (1) or pharmaceutically acceptable salts thereof； where R⁴ is H or C₁₋₆ alkyl；a. Each r83099 was selected separately from group ch832323；C₁₋₆ alkoxy,halo -CN -NO- (L) -SR- (L) -S (3DO) R- (L) -S (3DO) R- (L) -NHS (3DO) R- (L) -C (3DO) R- (L) -OC (3DO) R- (L) -CO R- (L) -OCO R- (L) -N (R)- (L) -C (3DO) N (R)- (L) -OC (3DO) N (R)- (L) -NHC (3DO) NH (R)- (L) -NHC (3DO) R- (L) -NHC (3DO) OR- (L) -C (OH) (R)- (L) -C (NH) (R)-Halide c83218c83331-832626；-dihaloalkyl C₁₋₆ and -trihaloalkyl C₁₋₆；L is independently, in each case, a bivalent radical selected from - (C₁₋₃ alkylene) -,- (cicloalquilen C) -- (rent C₁₋₃) ₘ-O- (rent C₁₋₃) ₘ-,o - (alquilen C) -NH- (alquilen C) -each R⁸ is independently, in each case, H, C₁₋₆ alkyl,-Halide c83218c83331-832626；-dihaloalkyl C₁₋₆,-trihaloalkyl C₁₋₆,3. Heterosexual c83218c31832626；C₃₋₁₀ cycloalkyl,e. Straight ring twelvearyl, heteroaryl, -C₁₋₄ alkyl (C₃₋₁₀ cycloalkyl),-C₁₋₄ alkyl (C₃₋₁₀ heterocycloalkyl),-alquil C - (arilo)or -C₁₋₄- (heteroaryl) alkyl,There, asphalt, ISO asphalt, cyclopropyl, ISO cyclopropyl, arilo and isomerized asphalt can be replaced by 1-5 alternatives selected from R2；R⁹ is C₁₋₆ alkyl,-Halide c83218c83331-832626；-dihaloalkyl C₁₋₆,-trihaloalkyl C₁₋₆,3. Heterosexual c83218c31832626；C₃₋₁₀ cycloalkyl,e. Straight ring twelvearyl, heteroaryl, -C₁₋₄ alkyl (C₃₋₁₀ cycloalkyl),-C₁₋₄ alkyl (C₃₋₁₀ heterocycloalkyl),-alquil C - (arilo)or -C₁₋₄- (heteroaryl) alkyl,There, tar, isopar, cyclopentadiene, isopropyl, arillo or heterocyclic rings are replaced by 0-5 substitutes selected from R2；R¹⁰ is OH, C₁₋₆ alkyl,alkyl C₁₋₆-OH, -haloalkyl C₁₋₆,-dihaloalkyl C₁₋₆,-trihaloalkyl C₁₋₆,3. Heterosexual c83218c31832626；C₃₋₁₀ cycloalkyl,e. Straight ring twelvearyl, heteroaryl, -C₁₋₄ alkyl (C₃₋₁₀ cycloalkyl),-C₁₋₄ alkyl (C₃₋₁₀ heterocycloalkyl),-alquil C - (arilo)or -C₁₋₄- (heteroaryl) alkyl,There, tar, isopar, cyclomethane, isocyclopropyl, arilo, or heterocyclomethylcyclohexane can be
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
