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INDOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS FOR INHIBITION OF FACTOR Xa
专利权人:
SANOFI-AVENTIS DEUTSCHLAND GMBH
发明人:
申请号:
IL16210504
公开号:
IL162105A
申请日:
2004.05.20
申请国别(地区):
IL
年份:
2012
代理人:
摘要:
The present invention relates to compounds of the formula I, <;CHEM>; in which R<;0>; ; R<;1>; ; R<;2>; ; R<;3>; ; R<;4>; ; R<;5>; ; R<;6>; ; R<;7>; ; Q; V, G and M have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardiovascular disorders like thromboembolic diseases or restenoses. They are reversible inhibitors of the blood clotting enzymes factor Xa (FXa) and/or factor VIIa (FVIIa), and can in general be applied in conditions in which an undesired activity of factor Xa and/or factor VIIa is present or for the cure or prevention of which an inhibition of factor Xa and/or factor VIIa is intended. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them
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