Anti-infective agents against intracellular pathogens

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专利权人:

发明人:

Ching-Shih Chen,Hao-Chieh Chiu,Dasheng Wang

申请号：

US13869386

公开号：

US08741944B2

申请日:

2013.04.24

申请国别(地区):

US

年份:

2014

代理人:

摘要：

A new class of phosphoinositide-dependent kinase-1 (PDK-1) inhibitors of Formula I:wherein X wherein X is —CF3, Ar is selected fromand R is selected fromwhere R′ is L-Lys, D-Lys, β-Ala, L-Lue, L-Ile, Phe, SO2CH2CH2NH2, SO2NH2, Asn, Glu or Gyl, and R″ is methyl, ethyl, allyl, CH2CH2OH, CH2CN, CH2CH2CN, CH2CONH2,

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