Ching-Shih Chen,Hao-Chieh Chiu,Dasheng Wang,John S. Gunn,Larry S. Schlesinger
申请号：
US13267943
公开号：
US08445483B1
申请日:
2011.10.07
申请国别(地区):
US
年份:
2013
代理人:
摘要：
A new class of phosphoinositide-dependent kinase-1 (PDK-1) inhibitors of Formula I:wherein X wherein X is —CF3, Ar is selected fromand R is selected fromwhere R′ is L-Lys, D-Lys, β-Ala, L-Lue, L-Ile, Phe, SO2CH2CH2NH2, SO2NH2, Asn, Glu or Gyl, and R″ is methyl, ethyl, allyl, CH2CH2OH, CH2CN, CH2CH2CN, CH2CONH2,
