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Low-substituted hydroxypropylcellulose and solid preparation comprising the same
专利权人:
Naosuke Maruyama
发明人:
Naosuke Maruyama,Yasuyuki Hirama
申请号:
US13043113
公开号:
US08822675B2
申请日:
2011.03.08
申请国别(地区):
US
年份:
2014
代理人:
摘要:
Provided is nonionic and excellently stable low-substituted hydroxypropylcellulose having improved compressibility and flowability, and further having improved disintegration and texture in oral cavity. More specifically provided is low-substituted hydroxypropylcellulose having a crystallinity of 60% or less, a degree of hydroxypropoxyl substitution of 5 to 9% by weight, and an aspect ratio of less than 2.5, wherein the crystallinity is calculated based on a diffraction intensity by wide-angle X-ray diffraction measurement according to the following formula (1):Crystallinity(%)={(Ic−Ia)/Ic}×100  (1)wherein Ic means a diffraction intensity at a diffraction angle 2θ of 22.5° and Ia means a diffraction intensity at a diffraction angle 2θ of 18.5°.
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