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METHOD OF SYNTHESIZING THYROID HORMONE ANALOGS AND POLYMORPHS THEREOF
专利权人:
MADRIGAL PHARMACEUTICALS;F. HOFFMANN-LA ROCHE LTD.; INC.;MADRIGAL PHARMACEUTICALS, INC.
发明人:
HESTER, D., KEITH,DUGUID, ROBERT, J.,KELLY, MARTHA,CHASNOFF, ANNA,DONG, GANG,CROW, EDWIN, L.,TAUB, REBECCA,REYNOLDS, CHARLES, H.,CHOI, DUK, SOON,SHU, LIANHE,WANG, PING
申请号:
SG11201501907Y
公开号:
SG11201501907YA
申请日:
2013.09.17
申请国别(地区):
SG
年份:
2015
代理人:
摘要:
The disclosure describes methods of synthesis of pyridazinone compounds as thyroid hormone analogs and their prodrugs. Preferred methods according to the disclosure allow for large-scale preparation of pyridazinone compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of pyridazinone compounds in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of a pyridazinone compound. Further disclosed is a method for treating resistance to thyroid hormone in a subject having at least one TRβ mutation.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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