Madrigal Pharmaceuticals, Inc.;Hoffmann-La Roche Inc.
发明人:
D. Keith Hester, II,Robert J. Duguid,Martha J. Kelly,Anna Chasnoff,Gang Dong,Edwin L. Crow,Duk Soon Choi,Lianhe Shu,Ping Wang
申请号：
US14660720
公开号：
US09266861B2
申请日:
2015.03.17
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The disclosure describes methods of synthesis of pyridazinone compounds as thyroid hormone analogs and their prodrugs. Preferred methods according to the disclosure allow for large-scale preparation of pyridazinone compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of pyridazinone compounds in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of a pyridazinone compound. Further disclosed is a method for treating resistance to thyroid hormone in a subject having at least one TRβ mutation.
