An orifice device (200a) for delivering one or more drugs includes an inner member (210) having a proximal end and a distal end； and a plurality of windings (220,220a) helically wound around the inner member. Each winding defines a separate layer and each winding includes at least one wire (222,222') helically wound around the inner member. The plurality of windings and the inner member define at least two separate channels (230,240) for carrying one or more drugs therethrough. An inlet is at the proximal end of each of the plurality of windings and an outlet is at the distal end of the plurality of windings. At least one of the plurality of windings may have a plurality of distinct wires helically wound in parallel around the inner member and at least one of the plurality of windings respectively. In some embodiments, the plurality of windings and the inner member define at least three separate channels for carrying one or more drugs therethrough. In some embodiments, at least two of the plurality of distinct wires have a different dimension. Additionally, an outer member is used over the plurality of windings. In some embodiments, at least one of the at least two separate channels has a different fluid flow rate. And, in other embodiments, at least two of the at least three separate channels have a different fluid flow rate. In some embodiments, at least one of the at least two separate channels carry a different drug. <；IMAGE>；
