ГЕССЛЕР Тобиас (DE),ШМЕЛЬ Томас (DE),ЗЕЕГЕР Вернер (DE),ФОСВИНКЕЛЬ Роберт (DE)
申请号：
RU2013151018/15
公开号：
RU2013151018A
申请日:
2012.04.26
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A pharmaceutical composition containing an active ingredient selected from iloprost and its salts, for use as an aerosol for pulmonary administration to a patient in need thereof, wherein the amount of the composition containing an effective single dose of the active ingredient is presented in an aerosolized form for bolus inhalation during 2 min or less. 2. The composition according to claim 1, characterized in that for inhalation of the specified amount requires 12 respiratory maneuvers or less. The composition according to claim 2, characterized in that for inhalation of the specified amount requires 8 respiratory maneuvers or less. The composition according to claim 1, administered by an inhaler that is adapted to emit the composition in an aerosolized form at a yield rate of 0.5 ml / min or more. The composition according to claim 1, administered using an inhaler that is adapted to emit the composition in aerosolized form at a rate of 5 μg iloprost per minute or more. The composition according to claim 1, administered by an inhaler that is adapted to emit a predetermined volume of air without aerosol into the inhalation phase immediately after a predetermined volume of aerosol. The composition of claim 6, wherein a predetermined volume of air without an aerosol is emitted by an inhaler for a period of 0.2 to 2 seconds at the end of each inhalation phase. The composition according to claim 6 or 7, in which a given volume of aerosol is emitted by the inhaler for 3-6 seconds into the inhalation phase. The composition of claim 1, wherein the inhaler is selected among metered dose inhalers, soft mist inhalers and nebulizers with a vibrating mesh. The composition according to claim 1, where for inhaling the composition in an amount containing an effective single dose,1. Фармацевтическая композиция, содержащая активный ингредиент, выбранный среди илопроста и его солей, для применения в виде аэрозоля для легочного введения пациенту, нуждающемуся в этом, где количест
