PROBLEM TO BE SOLVED: To provide compositions of imatinib, phenylaminopyrimidine derivative and kinase inhibitor compounds that are suitable for inhalation delivery to the lungs, central nervous system and/or systemic compartment, and methods of using the same.SOLUTION: A unit dosage of an aqueous solution for nebulized inhalation administration comprises: about 0.01 mL to about 10 mL of water； and a nintedanib salt at a concentration of about 0.1 mg/mL to about 100 mg/mL, where the osmolality of the aqueous solution is from about 50 mOsmol/kg to about 2000 mOsmol/kg.SELECTED DRAWING: Figure 1COPYRIGHT: (C)2020,JPO&INPIT【課題】肺、中枢神経系、及び／又は全身の区画への吸入送達に適している、イマチニブ、フェニルアミノピリミジン誘導体、及びキナーゼ阻害剤の化合物の組成物、並びに、その使用方法の提供。【解決手段】約０．０１ｍＬから約１０ｍＬの水と；約０．１ｍｇ／ｍＬから約１００ｍｇ／ｍＬまでの濃度のニンテダニブ塩とを含む、噴霧化吸入投与用の水溶液の単位用量であって、ここで、水溶液のモル浸透圧は、約５０ｍＯｓｍｏｌ／ｋｇから約２０００ｍＯｓｍｏｌ／ｋｇである、水溶液の単位用量。【選択図】図１
