An improved process for the isolation of temozolomide

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专利权人:

CIPLA LIMITED

发明人:

SRINIVAS, PATHI,RAO, DHARMARAJ RAMACHANDRA,KANKAN, RAJENDRA NARAYANRAO

申请号：

EP11160038

公开号：

EP2374807A3

申请日:

2007.09.28

申请国别(地区):

EP

年份:

2012

代理人:

摘要：

The present invention relates to a process for isolating temozolomide from an acidic solution containing temozolomide comprising subjecting the acidic solution of temozolomide to a counter-current continuous liquid-liquid extraction using water immiscible solvent. The present invention also relates to a process for purifying temozolomide comprising refluxing temozolomide in an acetone-water mixture having a pH from 2.5 to 4.5 followed by recovering purified temozolomide.

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