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DOSING AND MONITORING PATIENTS ON NITROGEN-SCAVENGING DRUGS
专利权人:
Bruce Scharschmidt
发明人:
Bruce Scharschmidt
申请号:
US13061509
公开号:
US20120022157A1
申请日:
2009.08.27
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The invention provides a method for determining a dose and dosing schedule, and making dose adjustments of patients taking PBA prodrugs as nitrogen scavengers to treat nitrogen retention states, including ammonia accumulation disorders as well as chronic renal failure, by measuring urinary excretion of phenylacetylglutamine and/or total urinary nitrogen. The invention provides methods to select an appropriate dosage of a PBA prodrug based on the patient's dietary protein intake, or based on previous treatments administered to the patient. The methods are applicable to selecting or modifying a dosing regimen for a subject receiving an orally administered waste nitrogen scavenging drug, and to monitoring patients receiving such drugs.
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