Disclosed is a medical instrument coating, being coated on the surface of a nickel-titanium alloy component of a medical instrument. The medical instrument coating comprises an elementary copper phase, an amorphous titanium-containing substance and a transition layer comprising a copper-nickel intermetallic phase. Also mentioned is a preparation method for the medical instrument coating. A medical instrument comprising a copper-titanium coating has good blood compatibility, and simultaneously can inhibit the endothelialization of the medical instrument surface, thereby improving the recovery rate of the medical instrument and prolonging the recovery time window the copper-titanium coating belongs to the group of metal composite coatings, has a certain toughness and ductility, and avoids the large-amplitude deformation process of the medical instrument damaging the coating and the mechanical property and the coating quality of the medical instrument comprising a fine nickel-titanium alloy component are guaranteed by the method for preparing the coating.
