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RÉGULATION DE L'HOMÉOSTASIE DE L'ACIDE URIQUE
专利权人:
ETH Zurich
发明人:
申请号:
EP10722931.2
公开号:
EP2432496B1
申请日:
2010.05.06
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
The invention relates to vectors and mammalian cells in a system useful for switching on or switching off gene expression in response to uric acid. In a particular embodiment the invention relates to a mammalian cell useful in detecting and/or degrading a harmful excess of uric acid comprising (a) a vector comprising a genetic code for the uricase sensor-regulator HucR from Deinococcus radiodurans R1 fused to a transactivation domain or a transrepressor domain; and (b) a vector comprising the corresponding operator sequence hucO from Deinococcus radiodurans R1 specifically binding the bacterial uric acid sensor-regulator HucR, a promoter and a polynucleotide coding for an endogenous or exogenous protein, e.g. a protein interacting with uric acid.
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