Chassagne Pierre,Khanzhin Nikolay,Hederos Markus Jondelius,Champion Elise,Matwiejuk Martin,Dekany Gyula
申请号：
US201414783783
公开号：
US10005807(B2)
申请日:
2014.04.11
申请国别(地区):
美国
年份:
2018
代理人:
Neal, Gerber & Eisenberg LLP
摘要：
An achemo-enzymatic synthesis of oligosaccharides of formula 1 is presented wherein R is selected from —OH, —N 3 and —OR 6 wherein R 6 is selected from allyl optionally substituted by one or more methyl, propargyl optionally substituted by one or more methyl, 2-trimethylsilyl-ethyl, —(CH 2) n —NH 2 and —(CH 2) n —N 3 wherein integer n is to 10, preferably 2 or 3, R is selected from sialyl moiety, —SO 3 H and —CH(R)—COOH wherein R is selected from H, alkyl and benzyl, R 2 is selected from H and fucosyl, R 3 is selected from H and sialyl, R 4 is selected from H and fucosyl, provided that at least one of R 3 and R 4 is H, and A is a divalent carbohydrate linker, having important biological activities and significant commercial value for the pharmaceutical and food industry.
