PROBLEM TO BE SOLVED: To provide a solid formulation capable of restraining effectively caking (solidification) and discoloration, even when using a hygroscopic natural medicine extract or Chinese medicine extract.SOLUTION: The solid formulation (pharmaceutical composition) is obtained by adsorbing the natural medicine extract or the Chinese medicine extract (soft extract containing 20-40 mass% of moisture content) into an adsorbent constituted of the first adsorbent (calcium silicate or the like) having 4-6 ml/g of adsorbability, and the second adsorbent (light silicic anhydride or the like) having adsorbability of 2 ml/g or more and less than 4 ml/g. The solid formulation (pharmaceutical composition) can prevent the caking (solidification), and coloring or the discoloration, even when a content of the component derived from a natural medicine is high. The solid formulation may contain further an antipyretic analgesic, and may contain also at least one selected from the group comprising a binder, an excipient, a disintegration agent and a flavoring agent.COPYRIGHT: (C)2013,JPO&INPIT【課題】吸湿性の生薬エキスまたは漢方エキスを用いても、ケーキング(固化)及び変色を有効に抑制できる固形製剤を提供する。【解決手段】吸着能が4~6ml/gである第1の吸着剤(ケイ酸カルシウムなど)と、吸着能が2ml/g以上であり、かつ4ml/g未満である第2の吸着剤(軽質無水ケイ酸など)とで構成された吸着剤に生薬エキスまたは漢方エキス(水分含有量20~40質量%の軟エキス)を吸着させ、固形製剤(医薬組成物)を得る。固形製剤は、生薬に由来する成分の含有量が高くても、ケーキング(固化)及び着色又は変色を防止できる。固形製剤は、さらに解熱鎮痛剤を含んでいてもよく、結合剤、賦形剤、崩壊剤および矯味剤から選択された少なくとも1つの成分を含有していてもよい。【選択図】なし
