Combining Radioimmunotherapy and Antibody-Drug Conjugates for Improved Cancer Therapy

• 收藏
• 分享

专利权人:

发明人:

Serengulam V. Govindan,David M. Goldenberg

申请号：

US15003297

公开号：

US20160129140A1

申请日:

2016.01.21

申请国别(地区):

US

年份:

2016

代理人:

摘要：

Described herein are compositions and methods of use of radionuclide-antibody conjugates (for RAIT) and drug-antibody conjugates (ADC). The combination of RAIT and ADC was more efficacious than either RAIT alone, ADC alone, or the sum of effects of RAIT and ADC. The unexpected synergy resulted in decreased tumor growth rate and increased survival, with a high incidence of tumor-free survival in Capan-1 human pancreatic cancer xenografts in nude mice.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/