ADRIAN BLASER,ANDREW M. THOMPSON,BRIAN DESMOND PALMER,CHARLES Z. DING,DIANJUN D. CHEN,GENLIANG LU,HAMISH SCOTT SUTHERLAND,IVETA KMENTOVA,JIANCHENG WANG,KEITH COMBRINK,MINSOO SONG,WILLIAM ALEXANDER DEN
申请号：
BRPI0909028
公开号：
BRPI0909028A2
申请日:
2009.03.25
申请国别(地区):
BR
年份:
2015
代理人:
摘要：
The current invention provides a series of bicyclic nitroimidazole-substituted phenyl oxazolidinones in which a bicyclic nitroimidazole pharmacophore is covalently bonded to a phenyl oxazolidinone, their pharmaceutical compositions, and the method of use of the compositions for prevention and treatment of bacterial infections. The bicyclic nitroimidazole-substituted phenyl oxazolidinones possess surprising antibacterial activity against wild-type and resistant strains of pathogens, and are therefore useful for the prevention, control and treatment of a number of human and veterinary bacterial infections caused by these pathogens, such as Mycobacterium tuberculosis.
