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ADJUVANT MENINGOCOCCUS PROTEIN BINDING FACTOR N
专利权人:
НОВАРТИС АГ (CH)
发明人:
КОНТОРНИ Марио (IT),ТАРЛИ Лоренцо (IT)
申请号:
RU2011142790/10
公开号:
RU2011142790A
申请日:
2010.03.24
申请国别(地区):
RU
年份:
2013
代理人:
摘要:
1. A buffered immunogenic composition containing at least two different meningococcal fHBP antigens, each of which is adsorbed at least 85% on an aluminum hydroxyphosphate adjuvant. The composition of claim 1, wherein (i) each of two different fHBP antigens has an isoelectric point between 5.0 and 7.0 and (ii) an aluminum hydroxyphosphate adjuvant has a zero charge point between 5.0 and 7.0.3. The composition according to claim 2, where the pH of the buffered composition is in the range from 5.0 to 7.0.4. The composition of claim 1, wherein (i) both meningococcal fHBP antigens have an isoelectric point between 5.0 and 6.0 and (ii) aluminum hydroxyphosphate has an isoelectric point between 5.0 and 6.0.5. The composition according to claim 4, where the immunogenic composition comprises a buffer to maintain a pH from 5.0 to 7.0.6. The composition of claim 5, wherein the immunogenic composition comprises a buffer to maintain a pH from 5.0 to 6.0.7. The composition of claim 4, wherein the composition does not include an aluminum hydroxide adjuvant. The composition according to claim 7, containing a conjugated bacterial capsular saccharide. The composition of claim 4, wherein the two different fHBP antigens are: (a) a first polypeptide comprising an amino acid sequence having at least 95% sequence identity with SEQ ID NO: 4; and (b) a second polypeptide comprising an amino acid sequence having at least 95% sequence identity with SEQ ID NO: 6.10. The composition of claim 9, wherein the first polypeptide is a lipoprotein having the amino acid sequence of SEQ ID NO: 23, and the second polypeptide is a lipoprotein having the amino acid sequence of SEQ ID NO: 25.11. The composition of claim 1, wherein two different fHBP antigens are1. Забуференная иммуногенная композиция, содержащая по меньшей мере два различных менингококковых антигена fHBP, каждый из которых, по меньшей мере, на 85% адсорбируется на адъюванте гидроксифосфате алюминия.2. Композиция по п.1, где (i) каждый из д
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