The present invention provides a polynucleotide adjuvant composition and methods of use in eliciting an immune response. The present invention also provides an immunogenic composition comprising the polynucleotide adjuvant composition together with an antigen (e.g., as in a vaccine). The adjuvant compositions of the invention have particular physical properties (e.g., molecular weight, concentration, and pH) which address the need for a safe adjuvant for eliciting an enhanced immune response. The present invention further contemplates methods of use of such adjuvant compositions, particularly in eliciting an immune response to an antigenic compound.本發明提供一種聚核苷酸佐劑組成物以及引發免疫反應的使用方法。本發明亦提供一種免疫原組成物,包含該聚核苷酸佐劑組成物和抗原(例如此二種成份位於一疫苗內)。本發明的佐劑組成物具有特定的物理性質(例如分子量、濃度和pH),這些性質能符合所需的一種誘導增強免疫反應的有效且安全的佐劑。本發明更思及這些佐劑組成物的使用方法,特別是誘導對於抗原化合物的免疫反應。
