Marianne Dorothy SADAR,Jun WANG,Nasrin R. MAWJI,Minoru KATO
申请号:
US15149298
公开号:
US20170056336A1
申请日:
2016.05.09
申请国别(地区):
US
年份:
2017
代理人:
摘要:
The present invention provides methods, compositions, and combinations for treating cancer via combined use of a compound of formula (I), and/or their subgenra, or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, R8, R9, R11a, R11b, R11c, and R11d are as defined herein, and at least one therapeutically active agents selected from inhibitors of PI3K/AKT/mTOR pathway, active agents associated with the treatment of prostate cancer, and anticancer agents.