SHANGAHI INSTITUTES FOR BIOLOGICAL SCIENCES; CHINESE ACADEMY OF SCIENCES; CHINESE ACADEMY OF SCIENC
发明人:
JING, QING,QIU, XIAOXU,LIU, YANG,ZHANG, YIFAN
申请号：
CA3012064
公开号：
CA3012064A1
申请日:
2017.01.12
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
Disclosed is a small molecule compound composition that efficiently induces the differentiation of human pluripotent stem cells into myocardial cells. In particular, provided in the present invention is a small molecule compound composition. The small molecule compound composition comprises the following components: (i) an mTOR signaling pathway inhibitor； (ii) a Wnt pathway promoter； and (iii) optionally, a pharmaceutically acceptable carrier. The small molecule compound composition in the present invention can efficiently induce the differentiation of human pluripotent stem cells into myocardial cells. The preliminarily screened cardiomyocyte differentiation rate reaches up to 86%, and the optimized cardiomyocyte differentiation rate reaches up to 98.3%.
