The present disclosure provides engineered antibodies that bind Globo H with high affinity and have increased stability against undesirable chemical modifications and large aggregate formation that can occur under high expression manufacturing conditions. The disclosure also provides methods of manufacturing, pharmaceutical formulations, and uses of the engineered antibodies for the treatment of cancer.本發明提供經改造抗體,其以高親和力結合Globo H且具有增加的穩定性對抗可在高表現製造條件下發生之不期望化學修飾及大聚集物形成。本發明亦提供該等經改造抗體之製造方法、醫藥調配物及用於治療癌症之用途。
