The present invention discloses hemostat devices and preparation method thereof. Disclosed hemostat devices include non-oxide polysaccharide derivates composition. Non-oxide polysaccharide derivates composition includes at least one polymer and at least one counter ion. Non-oxide polysaccharide derivates composition is configured to interact by hydro-combination process and blood, and wherein polymer interacts when at least one counter ion is dissociated with the water component of blood.