Described is a needle assembly retainer (1) comprising a body (2) adapted to hold a needle assembly (10). The needle assembly (10) comprises a hub (11) having an external surface (14) with at least one spline (15) and a needle having a proximal tip (10.1) and a distal tip (10.2). The body (2) has a proximal portion adapted to hold the hub (11) and a distal portion adapted to cover the distal tip (10.2). The needle assembly retainer (1) further comprises a resilient arm (6) formed on the proximal portion and adapted to engage the at least one spline (15) when the needle assembly (10) is rotated relative to the body (2).