Disclosed are a method for producing an aripiprazole suspension, wherein the aripiprazole has a mean particle size of 1 to 10 μm, the method comprising the steps of: (a) combining bulk aripiprazole and a vehicle to form a primary suspension (b) subjecting the primary suspension to first pulverization using e.g., a high shear pulverizing machine, a dispersion machine that applies shear force to a material to be processed, a colloid mill, an ultrasonic dispersion machine, or a high-pressure jet type emulsifying dispersion machine to form a secondary suspension and (c) subjecting the secondary suspension to second pulverization using e.g., a high-pressure jet type emulsifying dispersion machine to form a sterile final suspension and a method for producing a freeze-dried formulation from the aripiprazole suspension.揭示一種用於產製阿立哌唑懸浮液之方法,其中該阿立哌唑具有1至10微米之平均粒子尺寸,該方法包含以下步驟:(a)結合鬆散的阿立哌唑與載劑以形成一級懸浮液;(b)使用例如高切變粉碎機、對欲被加工之材料施加切變力之分散機、膠體磨機、超音波分散機、或高壓噴射型乳化分散機,令該一級懸浮液進行第一粉碎作用,以形成二級懸浮液;及(c)使用例如高壓噴射型乳化分散機,令該二級懸浮液進行第二粉碎作用,以形成無菌之最終懸浮液;及揭示一種用於由該阿立哌唑懸浮液產製冷凍乾燥調配物之方法。
