DISCLOSED ARE A METHOD FOR PRODUCING AN ARIPIPRAZOLE SUSPENSION, WHEREIN THE ARIPIPRAZOLE HAS A MEAN PARTICLE SIZE OF 1 TO 10 µM, THE METHOD COMPRISING THE STEPS OF: (A) COMBINING BULK ARIPIPRAZOLE AND A VEHICLE TO FORM A PRIMARY SUSPENSION (B) SUBJECTING THE PRIMARY SUSPENSION TO FIRST PULVERIZATION USING E.G., A HIGH SHEAR PULVERIZING MACHINE, A DISPERSION MACHINE THAT APPLIES SHEAR FORCE TO A MATERIAL TO BE PROCESSED, A COLLOID MILL, AN ULTRASONIC DISPERSION MACHINE, OR A HIGH—PRESSURE JET TYPE EMULSIFYING DISPERSION MACHINE TO FORM A SECONDARY SUSPENSION AND (C) SUBJECTING THE SECONDARY SUSPENSION TO SECOND PULVERIZATION USING E.G., A HIGH—PRESSURE JET TYPE EMULSIFYING DISPERSION MACHINE TO FORM A STERILE FINAL SUSPENSION AND A METHOD FOR PRODUCING A FREEZE-DRIED FORMULATION FROM THE ARIPIPRAZOLE SUSPENSION.
