Jane Rapsey;Martin Svehla;Christopher Robert Miller;Peter Schuller
发明人:
Jane Rapsey,Martin Svehla,Peter Schuller,Christopher Robert Miller
申请号：
US14064354
公开号：
US20140188033A1
申请日:
2013.10.28
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Implantable drug-doped component, e.g., a cochlear implant, including host material, a host-embedded drug, a sacrificial material integrated with the host. Sacrificial material facilitates release of drug from the component. Sacrificial material facilitates release through creation of voids in the host upon dissolution of sacrificial material upon contact with a solvent, e.g., perilymph fluid upon implant. Host can be polysiloxane, or silicone rubber. Drug can be anti-inflammatory, growth factor, antibody, anti-oxidant, antibiotic, corticosteroid. Sacrificial material can be: glucose monomer, sugar, cyclodextrin, dissolvable or resorbable at implant site, a salt, bioresorbable material, hyaluronic acid, polyurethane, polyester, polyamide, polyvinyl alcohol, polyacrylic acid. Sacrificial material can be the host, and can facilitate release of drug through changing a property of sacrificial material, e.g., by exposing component to ethanol wash. For a cochlear implant, drug doped material can be applied to a non-stimulating surface of the electrode array, and can be a physical feature of stimulating medical device, e.g., soft tip, ridge, spine. For a cochlear implant the drug-doped material can excluded from the basal side of the most basal electrode contact.
