WONG, BING LOU,黄炳鏐,黃炳鏐,WAI, NORMAN FUNG MAN,衞凤文,衞鳳文,KWOK, SUI YI,郭瑞仪,郭瑞儀,LAU, SZE HANG,刘思行,劉思行
申请号：
TW102136951
公开号：
TW201414489A
申请日:
2013.10.14
申请国别(地区):
TW
年份:
2014
代理人:
摘要：
The present invention provides a pharmaceutical composition containing a hemoglobin-based oxygen carrier for treating cancer, preventing recurrence and metastasis of cancerous tumor. The composition can be used alone or in combination with at least one chemotherapeutic agent such as 5FU, Bortezomib, doxorubicin, cisplatin, or any combination thereof. The hemoglobin-based oxygen carrier in the composition is capable of targeting a surface receptor expressed on cancerous cells and facilitating the uptake of both hemoglobin-based oxygen carrier and the chemotherapeutic agent by the cancerous cells via a receptor-mediated mechanism. The hemoglobin-based oxygen carrier inhibits the expression of hypoxic response elements such as HIF1 α, VEGF, ET1, VHL, etc. The pharmaceutical composition of the present invention is also useful for inducing the apoptosis or cell death of a type of self-renewing and tumor-initiating cells called cancer stem cells which are located in the hypoxic niche of a cancerous tumor.本發明提供一種用於治療癌症、預防癌性腫瘤復發及轉移之含有基於血紅素的氧載體之醫藥組成物。該組成物可單獨或與諸如5FU、硼替佐米、阿黴素、順鉑或其任何組合之至少一種化學治療劑組合使用。該組成物中之該基於血紅素之氧載體能夠靶向在癌細胞上表現之表面受體，且經由受體介導機制促進基於血紅素之氧載體及該化學治療劑由該癌細胞攝取。該基於血紅素之氧載體抑制諸如HIF1 α、VEGF、ET1、VHL等之低氧反應元件之表現。本發明之該醫藥組成物亦適用於誘導稱為癌症幹細胞之一類自我更新及腫瘤引發的細胞之細胞凋亡或細胞死亡，該細胞定位於癌性腫瘤之低氧龕中。
