So Jin Lee;Seung Young Lee;Kuiwon Choi;Ick Chan Kwon;Kwang Meyung Kim;Myung Sook Huh
发明人:
Kwang Meyung Kim,Ick Chan Kwon,Kuiwon Choi,Myung Sook Huh,Seung Young Lee,So Jin Lee
申请号：
US12905212
公开号：
US09061068B2
申请日:
2010.10.15
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Disclosed is a polymer-siRNA delivery carrier in which a siRNA is combined with a polymer and the use thereof. More specifically, there is disclosed a stable in vivo polymer-siRNA delivery carrier in which a polymer and a siRNA are combined by using charge interaction and biodegradable covalent bonding at the same time and the use thereof.The polymer-siRNA delivery carrier in which a polymer and a siRNA are combined by using charge interaction and biodegradable covalent bonding at the same time has a high siRNA deliver efficiency to a target portion in vivo. Hence, according to the polymer-siRNA binder, the siRNA for treatment can be effectively delivered to a target portion such as in vivo cancer tissue, and the like even with administration of a relatively low concentration, and thus widely used for the treatment of various kinds of diseases.
