The invention provides pharmaceutical stable semisolid topical compositions comprising between 0.2 to 5% of a des-fluoroquinolone compound, and a suitable carrier to manufacture an ointment or a cream.本發明提供一種穩定半固體醫藥局部組成物,其包含介於0.2%至5%之間的脫氟喹啉酮(des-fluoroquinolone)化合物及適於製造軟膏或乳膏之載劑。