HEENEY, JONATHAN,MOOIJ, PETRA,GOMEZ RODRIGUEZ, CARMEN ELENA,NAJERA GARCIA, JOSE LUIS,JIMENEZ TENTOR, VICTORIA,ESTEBAN RODRIGUEZ, MARIANO
申请号：
DK06778467
公开号：
DK1921146T3
申请日:
2006.07.25
申请国别(地区):
DK
年份:
2012
代理人:
摘要：
Recombinant vector (A) derived from modified Ankara virus (MVA) that expresses simultaneously (i) a form of the Env protein of HIV-1 that lacks the region corresponding to the whole of gp41 and (ii) a fusion protein (FP) containing sequences of the Gag, Pol and Nef genes of HIV-1, where the sequences encoding (i) and (ii) are under control of identical promoters and are inserted into the same site in the vector. Independent claims are included for the following: (1) similar vector (A1) in which FP and the Gag-Pol-Nef fusion are from simian immune deficiency virus (SIV)； (2) recombinant vector (A2) derived from NYVAC virus having the same genomic organization, insertion sites and promoters as (A1)； and (3) plasmid (P) used as intermediate for construction and/or characterization of (A1). ACTIVITY : Ant-HIV. No details of tests for anti-HIV activity are given. MECHANISM OF ACTION : Vaccine.
