Carmen Elena Gomez Rodriguez;Jose Luis Najera Garcia;Victoria Jimenez Tentor;Mariano Esteban Rodriguez;Jonathan Heeney;Petra Mooij
发明人:
Jonathan Heeney,Petra Mooij,Carmen Elena Gomez Rodriguez,Jose Luis Najera Garcia,Victoria Jimenez Tentor,Mariano Esteban Rodriguez
申请号：
US11989425
公开号：
US08871219B2
申请日:
2006.07.25
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Recombinant vectors which are based on the Modified Ankara Virus (MVA) as preventive and therapeutic vaccines against AIDS. The recombinant viruses contain sequences which are inserted at an MVA insertion site and enable simultaneous expression of antigens, a HIV-1 Env protein consisting of a gp120 protein lacking sequences corresponding to protein gp 41 and a chimeric fusion protein of Gag, Pol and Nef. These viruses are stable and can trigger immune responses against a large variety of antigens. Viruses having a chimeric protein from HIV-1 are suitable for the preparation of vaccines against AIDS.
