The present disclosure is directed to a Foley catheter drainage collection system which is capable of permitting the removal and reconnection of drainage bags without compromising the sterility of the drainage system lumen. The collection system has a tubing element (16) which includes a drainage valve (18) associated with an end thereof remote from the insertion end of a Foley catheter. The drainage valve (18) associated with the tubing element (16) is movable from an open catheter drainage position to a closed position. The collection system also includes a drainage bag (20) having a first connector element (24) associated therewith and a second connector element (26) is associated with the drainage valve (18). The second connector element (26) is adapted for mating engagement with the first connector element (24). The collection system further includes a retaining element (28) for maintaining the connector elements (24,26) in mating engagement when the drainage valve (18) is disposed in the open catheter drainage position.