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BONE FILLING MATERIAL FOR MEDICAL OR VETERINARY USE, PROCESS FOR OBTAINING SAME, MATERIAL OBTAINED AND APPLICATIONS THEREOF
专利权人:
CATHERINE CADOREL
发明人:
CATHERINE CADOREL
申请号:
FR1004325
公开号:
FR2967073A1
申请日:
2010.11.04
申请国别(地区):
FR
年份:
2012
代理人:
摘要:
This process, which is very easy to implement and inexpensive, makes it possible to obtain an osteomimetic material which combines good general mechanical properties and excellent biocompatibility in terms of biological acceptance of the graft type, capable of allowing a particularly effective use in medical fields, veterinary, as well as in the fields of robotization. The process according to the present invention consists in homogeneously mixing a biocompatible thermoplastic polymer with tricalcium phosphate of the beta type: β TCP Ca 3 (PO 4) 2. The resulting mixture is then subjected to an injection molding or extrusion molding operation, under suitable conditions (temperature and pressure in particular) to ensure the transformation of the tricalcium phosphate absorbable crystals of non-stoichiometric calcium apatite resorbable In addition, the base composition, before molding, can advantageously comprise one or more agents capable of promoting the formation of non-stoichiometric calcium apatite such as phosphoric acid and / or capable of improving the radiopacity of the molded mixture. It is thus possible to add one or more biocompatible metal oxides. This material promotes and develops transmembrane metabolic exchanges. It allows the cells to integrate its surface to a depth close to 900 nanometers and to bind with said material through covalent bonds grouping mainly nitrogen functions. This material thus achieves a graft-type principle. The nanotechnological material thus produced will find applications in all orthopedic fields because of its connections, and its physico-chemical mimicry with bone tissues.Ce procédé très facile à mettre en œuvre, peu coûteux, permet l'obtention d'un matériau ostéomimétique qui combine de bonnes qualités mécaniques générales et une excellente biocompatibilité en termes d'acceptation biologique de type greffe, susceptible de permettre une utilisation particulièrement efficace dans les domaines médicaux, vétérinaires, ains
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中国工程科技知识中心
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