The disclosure relates to a new and distinct variety of lettuce variety NUN 01201 LTL as well as seeds and plants and heads or leaves thereof. NUN 01201 LTL is a short-day Iceberg lettuce variety for the Mediterranean cool autumn comprising resistance Downy Mildew (Bremia lactucae) isolates B1:16-36 EU and Nasonovia ribisnigri Biotype Nr:0.