The disclosure relates to lettuce variety NUN 06186 LTL as well as seeds and plants and heads or leaves thereof. Lettuce variety NUN 06186 LTL is a Romaine Mediterranean lettuce variety for the summer season, comprising resistance to Bremia lactucae B1:16-35 EU, Nasonovia ribisnigri Biotype Nr:0, and Lettuce Necrotic Spot Virus (LNSV).