THE GOVERNMENT OF THE UNITED STATES OF AMERICA; AS REPRESENTED BY THE SECRETARY; DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人:
申请号:
EP07874019.8
公开号:
EP2062023B2
申请日:
2007.08.24
申请国别(地区):
EP
年份:
2016
代理人:
摘要:
The present invention relates to a method of stabilizing an insert in a recombinant vaccinia virus by disrupting a run of 4 or more G or C residues through a substitution that introduces a silent mutation in the run, the length of which is thereby reduced.