PURANDARE, ASHOK V.,GREBINSKI, JAMES W.,HART, AMY,INGHRIM, JENNIFER,SCHROEDER, GRETCHEN,WAN, HONGHE
申请号：
PE2012000289
公开号：
PE20121150A1
申请日:
2010.09.02
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
REFERRED TO A COMPOUND OF FORMULA I, WHERE X IS C1-C4 ALKYL； Y IS C1-C4 ALKYL； R IS 4-METHYLTIAZOLE, 4-THERBUTYL THIAZOLE, 4- (PIRIDIN-2-IL) -TIAZOLE, 5-METHYLTIAZOLE, AMONG OTHERS. THEY ARE PREFERRED COMPOUNDS: N, N-DICILOPROPIL-6-ETIL-1-METHYL-4- (THIAZOL-2-ILAMINO) -1,6-DIHIDROIMIDAZO [4,5-d] PIRROLO [2,3-b] PIRIDIN- 7-CARBOXAMIDE； 4- (4-TERC-BUTYLTIAZOL-2-ILAMINO) -N, N-DICICLOPROPIL-6-ETIL-1-METHYL-1,6-DIHIDROIMIDAZO [4,5-d] PIRROLO [2,3-b] PIRIDIN- 7-CARBOXAMIDE； 2- (7- (DICICLOPROPILCARBAMOIL) -6-ETIL-1-METHYL-1,6-DIHIDROIMIDAZO [4,5-d] PIRROLO [2,3-b] PIRIDIN-4-ILAMINO) -N, N-DIMETILTIAZOL- 4-CARBOXAMIDE； AMONG OTHERS. SUCH COMPOUNDS INHIBIT THYROSINE KINASE JAK2 ACTIVITY,Use as an anti carcinogen in the treatment of cancer and other diseasesREFERIDA A UN COMPUESTO DE FORMULA I, DONDE X ES ALQUILO C1-C4； Y ES ALQUILO C1-C4； R ES 4-METILTIAZOL, 4-TERCBUTIL TIAZOL, 4-(PIRIDIN-2-IL)-TIAZOL, 5-METILTIAZOL, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N,N-DICILOPROPIL-6-ETIL-1-METIL-4-(TIAZOL-2-ILAMINO)-1,6-DIHIDROIMIDAZO[4,5-d]PIRROLO[2,3-b]PIRIDIN-7-CARBOXAMIDA； 4-(4-TERC-BUTILTIAZOL-2-ILAMINO)-N,N-DICICLOPROPIL-6-ETIL-1-METIL-1,6-DIHIDROIMIDAZO[4,5-d]PIRROLO[2,3-b]PIRIDIN-7-CARBOXAMIDA； 2-(7-(DICICLOPROPILCARBAMOIL)-6-ETIL-1-METIL-1,6-DIHIDROIMIDAZO[4,5-d]PIRROLO[2,3-b]PIRIDIN-4-ILAMINO)-N,N-DIMETILTIAZOL-4-CARBOXAMIDA； ENTRE OTROS. DICHOS COMPUESTOS INHIBEN LA ACTIVIDAD TIROSINA CINASA JAK2, UTILES COMO AGENTES ANTIPROLIFERATIVOS EN EL TRATAMIENTO DE CANCER Y OTRAS ENFERMEDADES
