BANDYOPADHYAY, DEEPAK,EIDAM, PATRICK M.,GOUGH, PETER J.,HARRIS, PHILIP ANTHONY,JEONG, JAE U.,KANG, JIANXING,KING, BRYAN WAYNE,LAKDAWALA SHAH, AMI,LEISTER, LARA KATHRYN,MARQUIS, JR., ROBERT W.,RAHMAN,
申请号：
PE0017272015
公开号：
PE17522015A1
申请日:
2014.02.14
申请国别(地区):
PE
年份:
2015
代理人:
摘要：
Light compounds having the formula (i), where z is o, s or CH2, etc and it is ch2ch2 Z1 is n, CH, etc Z2 is CH, etc Z3 is n, CH, Z4 is CH, etcEtc R5 is H or Methyl ra is c1-c4 alkyl, etc. b is phenyl, phenyl, etc it is 1 m or L IS o, S, etc.Preferred compounds are: 4 - Benzyl - (N - methyl - 5 - 4 - oxo - tetrahidrobenzo 2,3,4,5 [b] [1,4] tiazepin - 3 - il) isoxazole - 3 - carboxamide 3 - Benzyl - (N - (S) - 5 - methyl - 4 - oxo - [b tetrahidrobenzo 2,3,4,5 [1],Oxazepin] - 3 - 4 - 1 - il) piperidine carboxamide among othersSe desvelan compuestos que tienen la formula (I) donde: Z es O, S, etc Y es CH2 o CH2CH2 Z1 es N, CH, etc Z2 es CH, etc Z3 es N, CH, etc Z4 es CH, etc R5 es H o metilo RA es alquilo C1-C4 A es fenilo, etc B es fenilo, etc m es O o 1 L es O, S, etc. Son compuestos preferidos: 5-Bencil-N-(5-metil-4-oxo-2,3,4,5-tetrahidrobenzo[b][1,4]tiazepin-3-il)isoxazol-3-carboxamida 3-Bencil-N-((S)-5-metil-4-oxo-2,3,4,5-tetrahidrobenzo[b][1,4]oxazepin-3-il)piperidina-1-carboxamida entre otros
