The present invention provides a pharmaceutical composition containing a selenite-containing compound and a pharmaceutically acceptable acid, selected from citric acid, acetic acid, malic acid, carbonic acid, sulfuric acid, nitric acid, hydrochloric acid, fruit acids and mixtures thereof. This composition is for use in the prevention or treatment of an infection of an internal reproductive organ of a female patient with at least one human papillomavirus (HPV) selected from HPV16, HPV18, HPV31, HPV33 and HPV58. The composition is applied intravaginally.本發明提供一種醫藥組合物，包含一含有亞硒酸鹽之化合物及一醫藥上可接受之酸，該酸係選自檸檬酸、醋酸、蘋果酸、碳酸、硫酸、硝酸、鹽酸、果酸及其混合。該醫藥組合物係用於預防或治療受到至少一種人類乳突病毒(HPV)感染之人類女性患者的內生殖器官，該人類乳突病毒係選自HPV16、HPV18、HPV31、HPV33及HPV58。該組合物係經陰道內投藥。
