SOUTHERN RESEARCH INSTITUTE;THE UAB RESEARCH FOUDATION
发明人:
SUTO, MARK, J.,MURPHY-ULLRICH, JOANNE, E.
申请号：
CA2910196
公开号：
CA2910196A1
申请日:
2014.05.09
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
The present disclosure relates to compounds, compositions and methods for the treatment of diseases through inhibiting the activity of the transforming growth factor beta (TGF-ß). More specifically, the disclosed compounds, compositions and methods are useful in the treatment of certain cancers (e.g. multiple myeloma, hematologic malignancies), diseases associated with excessive TGF-ß activity including fibrosis, dermal scarring, immune dysfunction, and bone loss by inhibiting the conversion of latent TGF-ß to active TGF-ß. A method of preventing the activation of TGF-ß in pathology is also provided, comprising administering an amount of the compounds sufficient to inhibit conversion of latent TGF-ß to active TGF-ß by thrombospondin 1 (TSP1), resulting in reduced TGF-ß activity and reduced adverse effects such as fibrosis, bone loss, and immune dysfunction.
