CD40L-specific Tn3-derived scaffolds and methods of use thereof

• 收藏
• 分享

专利权人:

LLC;MedImmune

发明人:

Coyle, Anthony,Baca, Manuel,Thisted, Thomas,Drabic, Stacey,Grinberg, Luba,Novarra, Shabazz,Oganesyan, Vaheh,Herbst, Ronald,Spencer, David Kenneth

申请号：

AU2012323316

公开号：

AU2012323316B2

申请日:

2012.10.10

申请国别(地区):

AU

年份:

2017

代理人:

摘要：

The present invention provides Tenascin-3 Fnlll domain-based scaffolds that specifically bind to CD40L. The invention further provides engineered variants with increased affinity for the target. The present invention is also related to engineered scaffolds as prophylactic, diagnostic, or therapeutic agents, in particular for therapeutic uses against SLE and other autoimmune diseases and conditions.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/