CD40L-specific Tn3-derived scaffolds and methods of use thereof

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专利权人:

メディミューン，エルエルシー

发明人:

コイル，アンソニー,バカ，マニュエル,システッド，トーマス,ドラビック，ステイシー,グリンバーグ，ルバ,ノバラ，シャバズ,オガネスヤン，バヘー,ハーブスト，ロナルド,スペンサー，デビッド，ケネス

申请号：

JP2017090963

公开号：

JP6539300B2

申请日:

2017.05.01

申请国别(地区):

JP

年份:

2019

代理人:

摘要：

The present invention provides Tenascin-3 FnIII domain-based scaffolds that specifically bind to CD40L. The invention further provides engineered variants with increased affinity for the target. The present invention is also related to engineered scaffolds as prophylactic, diagnostic, or therapeutic agents, in particular for therapeutic uses against SLE and other autoimmune diseases and conditions.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/