President and Fellows of Harvard College;Dana-Farber Cancer Institute, Inc.
发明人:
WALENSKY, LOREN D.,KORSMEYER, STANLEY J.,VERDINE, GREGORY
申请号：
PL04811198
公开号：
PL1680443T3
申请日:
2004.11.05
申请国别(地区):
PL
年份:
2014
代理人:
摘要：
Novel polypeptides and methods of making and using the same are described herein. The polypeptides include cross-linking ("hydrocarbon stapling") moieties to provide a tether between two amino acid moieties, which constrains the secondary structure of the polypeptide. The polypeptides described herein can be used to treat diseases characterized by excessive or inadequate cellular death.
